shaker.umh.es menu
CSS Drop Down Menu by PureCSSMenu.com


Publications → Papers → References

Partitioning of Liquid-ordered / Liquid-disordered Membrane Microdomains Induced by the Fluidifying Effect of 2-Hydroxylated Fatty Acid Derivatives. Maitane Ibarguren, David J. López, José A. Encinar, José M. González-Ros, Xavier Busquets and Pablo V. Escribá. 2013. Biochimica et Biophysica Acta 1828 (2013), 2553-2563.


  1. R.M. Epand, R.F. Epand, N. Ahmed, R. Chen, Promotion of hexagonal phase formation and lipid mixing by fatty acids with varying degrees of unsaturation, Chem. Phys. Lipids Chem. Phys. Lipids 57 (1991) 75-80.
  2. V. Demarin, M. Lisak, S. Morovic, Mediterranean diet in healthy lifestyle and prevention of stroke, Acta Clin. Croat. 50 (2011) 67-77.
  3. S.J. Baum, P.M. Kris-Etherton, W.C. Willett, A.H. Lichtenstein, L.L. Rudel, K.C. Maki, J. Whelan, C.E. Ramsden, R.C. Block, Fatty acids in cardiovascular health and disease: a comprehensive update, J. Clin. Lipidol. 6 (2012) 216-234.
  4. F. Barceló, J. Prades, S.S. Funari, J. Frau, R. Alemany, P.V. Escribá, The hypotensive drug 2-hydroxyoleic acid modifies the structural properties of model membranes, Mol. Membr. Biol. 21 (2004) 261-268.
  5. Q. Yang, R. Alemany, J. Casas, K. Kitajka, S.M. Lanier, P.V. Escribá, Influence of the membrane lipid structure on signal processing via G protein-coupled receptors, Mol. Pharmacol. 68 (2005) 210-217.
  6. P.V. Escribá, Use of Hydroxyoleic Acid and Similar Compounds in the Production of Medicaments. Spain, 2006. (EP 1435235B1 05.04.2006. Patent).
  7. P.V. Escribá, Membrane-lipid therapy: a new approach in molecular medicine, Trends Mol. Med. 12 (2006) 34-43.
  8. J. Martínez, A. Gutiérrez, J. Casas, V. Lladó, A. López-Bellán, J. Besalduch, A. Dopazo, P.V. Escribá, The repression of E2F-1 is critical for the activity of minerval against cancer, J. Pharmacol. Exp. Ther. 315 (2005) 466-474.
  9. O. Vögler, A. López-Bellán, R. Alemany, S. Tofe, M. González, J. Quevedo, V. Pereg, F. Barceló, P.V. Escribá, Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats, Int. J. Obes. (Lond.) 32 (2008) 464-473.
  10. P.V. Escribá, Use of Hydroxyoleic Acid and Related Compounds in the Manufac- ture of Drugs. USA, 2010. (US 7851507B2 Dec 14, 2010. Patent).
  11. V. Lladó, A. Gutiérrez, J. Martínez, J. Casas, S. Terés, M. Higuera, A. Galmes, C. Saus, J. Besalduch, X. Busquets, P.V. Escribá, Minerval induces apoptosis in Jurkat and other cancer cells, J. Cell. Mol. Med. 14 (2010) 659-670.
  12. S. Terés, V. Lladó, M. Higuera, G. Barceló-Coblijn, M.L. Martin, M.A. Noguera-Salva, A. Marcilla-Etxenike, J.M. García-Verdugo, M. Soriano-Navarro, C. Saus, U. Gómez-Pinedo, X. Busquets, P.V. Escribá, 2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy, Proc. Natl. Acad. Sci. 109 (2012) 8489-8494.
  13. J. Martínez, O. Vögler, J. Casas, F. Barceló, R. Alemany, J. Prades, T. Nagy, C. Baamonde, P.G. Kasprzyk, S. Terés, C. Saus, P.V. Escribá, Membrane structure modulation, protein kinase C alpha activation, and anticancer activity of minerval, Mol. Pharmacol. 67 (2005) 531-540.
  14. G. Barceló-Coblijn, M.L. Martin, R.F. de Almeida, M.A. Noguera-Salva, A. Marcilla-Etxenike, F. Guardiola-Serrano, A. Luth, B. Kleuser, J.E. Halver, P.V. Escribá, Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy, Proc. Natl. Acad. Sci. 108 (2011) 19569-19574.
  15. P.V. Escribá, A. Ozaita, C. Ribas, A. Miralles, E. Fodor, T. Farkas, J.A. García-Sevilla, Role of lipid polymorphism in G protein-membrane interactions: nonlamellar-prone phospholipids and peripheral protein binding to membranes, Proc. Natl. Acad. Sci. 94 (1997) 11375-11380.
  16. P.V. Escribá, M. Sastre, J.A. García-Sevilla, Disruption of cellular signaling pathways by daunomycin through destabilization of nonlamellar membrane structures, Proc. Natl. Acad. Sci. 92 (1995) 7595-7599.
  17. P.V. Escribá, P. Morales, A. Smith, Membrane phospholipid reorganization differ- entially regulates metallothionein and heme oxygenase by heme-hemopexin, DNA Cell Biol. 21 (2002) 355-364.
  18. D.J. López, M. Egido-Gabas, I. López-Montero, J.V. Busto, J. Casas, M. Garnier, F. Monroy, B. Larijani, F.M. Goñi, A. Alonso, Accumulated bending energy elicits neutral sphingomyelinase activity in human red blood cells, Biophys. J. 102 (2012) 2077-2085.
  19. G. Lenaz, Lipid fluidity and membrane protein dynamics, Biosci. Rep. 7 (1987) 823-837.
  20. H. Jerabek, G. Pabst, M. Rappolt, T. Stockner, Membrane-mediated effect on ion channels induced by the anesthetic drug ketamine, J. Am. Chem. Soc. 132 (2010) 7990-7997.
  21. A. Kopp Lugli, C.S. Yost, C.H. Kindler, Anaesthetic mechanisms: update on the challenge of unravelling the mystery of anaesthesia, Eur. J. Anaesthesiol. 26 (2009) 807-820.
  22. J.P. Huidobro-Toro, R.A. Harris, Brain lipids that induce sleep are novel modulators of 5-hydroxytrypamine receptors, Proc. Natl. Acad. Sci. 93 (1996) 8078-8082.
  23. B. Stancevic, R. Kolesnick, Ceramide-rich platforms in transmembrane signaling, FEBS Lett. 584 (2010) 1728-1740.
  24. M.B. Ruíz-Argüello, M.P. Veiga, J.L. Arrondo, F.M. Goñi, A. Alonso, Sphingomyelinase cleavage of sphingomyelin in pure and mixed lipid membranes. In?uence of the physical state of the sphingolipid, Chem. Phys. Lipids Chem. Phys. Lipids 114 (2002) 11-20.
  25. K. Simons, E. Ikonen, Functional rafts in cell membranes, Nature 387 (1997) 569-572.
  26. V. Michel, M. Bakovic, Lipid rafts in health and disease, Cell Biol. Organ. 99 (2007) 129-140.
  27. R. Ehehalt, P. Keller, C. Haass, C. Thiele, K. Simons, Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts, Eur. J. Cell Biol. 160 (2003) 113-123.
  28. M. Hashimoto, T. Takenouchi, E. Rockenstein, E. Masliah, Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease, J. Neurochem. 85 (2003) 1468-1479.
  29. A. Taraboulos, M. Scott, A. Semenov, D. Avrahami, L. Laszlo, S.B. Prusiner, Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform, J. Cell Biol. 129 (1995) 121-132.
  30. E.C. Jury, P.S. Kabouridis, F. Flores-Borja, R.A. Mageed, D.A. Isenberg, Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus, J. Clin. Invest. 113 (2004) 1176-1187.
  31. G. Del Real, S. Jiménez-Baranda, R.A. Lacalle, E. Mira, P. Lucas, C. Gómez-Mouton, A.C. Carrera, A.C. Martínez, S. Manes, Blocking of HIV-1 infection by targeting CD4 to nonraft membrane domains, J. Exp. Med. 196 (2002) 293-301.
  32. S.K. Patra, Dissecting lipid raft facilitated cell signaling pathways in cancer, Biochim. Biophys. Acta 1785 (2008) 182-206.
  33. T. Murai, The role of lipid rafts in cancer cell adhesion and migration, Int. J. cell biol. 2012 (2012) 763283.
  34. L.D. Mayer, M.J. Hope, P.R. Cullis, Vesicles of variable sizes produced by a rapid extrusion procedure, Biochim. Biophys. Acta 858 (1986) 161-168.
  35. M.B. Ruíz-Argüello, G. Basañez, F.M. Goñi, A. Alonso, Different effects of enzyme- generated ceramides and diacylglycerols in phospholipid membrane fusion and leakage, J. Biol. Chem. 271 (1996) 26616-26621.
  36. D. Hoekstra, Role of lipid phase separations and membrane hydration in phospholipid vesicle fusion, Biochem. 21 (1982) 2833-2840.
  37. A. Marcilla-Etxenike, M.L. Martin, M.A. Noguera-Salva, J.M. Garcia-Verdugo, M. Soriano-Navarro, I. Dey, P.V. Escriba, X. Busquets, 2-Hydroxyoleic acid induces ER stress and autophagy in various human glioma cell lines, PLoS One 7 (2012) e48235.
  38. I.M. Angelova, D.S. Dimitrov, Liposome electroformation, Faraday Discuss. Chem. Soc. 81 (1986) 303-311.
  39. M. Ibarguren, D.J. López, L.R. Montes, J. Sot, A.I. Vasil, M.L. Vasil, F.M. Goñi, A. Alonso, Imaging the early stages of phospholipase C/sphingomyelinase activity on vesicles containing coexisting ordered-disordered and gel-fluid domains, J. Lipid Res. 52 (2011) 635-645.
  40. F. Barceló, J. Prades, J.A. Encinar, S.S. Funari, O. Vögler, J.M. González-Ros, P.V. Escribá, Interaction of the C-terminal region of the Ggamma protein with model membranes, Biophys. J. 93 (2007) 2530-2541.
  41. N. Kahya, D. Scherfeld, K. Bacia, B. Poolman, P. Schwille, Probing lipid mobility of raft-exhibiting model membranes by fluorescence correlation spectroscopy, J. Biol. Chem. 278 (2003) 28109-28115.
  42. P. Akuthota, R.C. Melo, L.A. Spencer, P.F. Weller, MHC class II and CD9 in human eosinophils localize to detergent-resistant membrane microdomains, Am. J. Respir. Cell Mol. Biol. 46 (2012) 188-195.
  43. S.R. Shaikh, A.C. Dumaual, A. Castillo, D. LoCascio, R.A. Siddiqui, W. Stillwell, S.R. Wassall, Oleic and docosahexaenoic acid differentially phase separate from lipid raft molecules: a comparative NMR, DSC, AFM, and detergent extraction study, Biophys. J. 87 (2004) 1752-1766.
  44. J. Sot, M. Ibarguren, J.V. Busto, L.R. Montes, F.M. Goñi, A. Alonso, Cholesterol displacement by ceramide in sphingomyelin-containing liquid-ordered domains, and generation of gel regions in giant lipidic vesicles, FEBS Lett. 582 (2008) 3230-3236.
  45. R.F. de Almeida, L.M. Loura, A. Fedorov, M. Prieto, Lipid rafts have different sizes depending on membrane composition: a time-resolved fluorescence resonance energy transfer study, J. Mol. Biol. 346 (2005) 1109-1120.
  46. D. Huster, P. Muller, K. Arnold, A. Herrmann, Dynamics of membrane penetration of the fluorescent 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) group attached to an acyl chain of phosphatidylcholine, Biophys. J. 80 (2001) 822-831.
  47. H.H. Mantsch, R.N. McElhaney, Phospholipid phase transitions in model and bio- logical membranes as studied by infrared spectroscopy, Chem. Phys. Lipids 57 (1991) 213-226.
  48. H.H. Mantsch, A. Martin, D.G. Cameron, Characterization by infrared spectroscopy of the bilayer to nonbilayer phase transition of phosphatidylethanolamines, Biochem. 20 (1981) 3138-3145.
  49. P.L. Yeagle, W.C. Hutton, R.B. Martin, Sphingomyelin multiple phase behavior as revealed by multinuclear magnetic resonance spectroscopy, Biochem. 17 (1978) 5745-5750.
  50. R.M. Epand, R.F. Epand, Non-raft forming sphingomyelin-cholesterol mixtures, Chem. Phys. Lipids 132 (2004) 37-46.
  51. M.P. Veiga, J.L. Arrondo, F.M. Goñi, A. Alonso, D. Marsh, Interaction of cholesterol with sphingomyelin in mixed membranes containing phosphatidylcholine, studied by spin-label ESR and IR spectroscopies. A possible stabilization of gel-phase sphingolipid domains by cholesterol, Biochem. 40 (2001) 2614-2622.
  52. R.N.A.H. Lewis, McElhaney, Fourier transform infrared spectroscopy in the study of hydrated lipids and lipid bilayer membranes, in: H.H. Mantsch, D. Chapman (Eds.), Infrared Spectroscopy of Biomolecules, Wiley-Liss, New York, 1996, pp. 159-202.
  53. S. Terés, G. Barceló-Coblijn, M. Benet, R. Alvárez, R. Bressani, J.E. Halver, P.V. Escribá, Oleic acid content is responsible for the reduction in blood pressure induced by olive oil, Proc. Natl. Acad. Sci. 105 (2008) 13811-13816.
  54. C.J. Lavie, R.V. Milani, M.R. Mehra, H.O. Ventura, Omega-3 polyunsaturated fatty acids and cardiovascular diseases, J. Am. Coll. Cardiol. 54 (2009) 585-594.
  55. R. Kapoor, Y.S. Huang, Gamma linolenic acid: an antiinflammatory omega-6 fatty acid, Curr. Pharm. Biotechnol. 7 (2006) 531-534.
  56. J. Prades, S.S. Funari, P.V. Escribá, F. Barceló, Effects of unsaturated fatty acids and triacylglycerols on phosphatidylethanolamine membrane structure, J. Lipid Res. 44 (2003) 1720-1727.
  57. S.R. Shaikh, M. Edidin, Polyunsaturated fatty acids and membrane organization: elucidating mechanisms to balance immunotherapy and susceptibility to infection, Chem. Phys. Lipids Chem. Phys. Lipids 153 (2008) 24-33.
  58. A. Rebillard, X. Tekpli, O. Meurette, O. Sergent, G. LeMoigne-Muller, L. Vernhet, M. Gorria, M. Chevanne, M. Christmann, B. Kaina, L. Counillon, E. Gulbins, D. Lagadic-Gossmann, M.T. Dimanche-Boitrel, Cisplatin-induced apoptosis involves membrane ?uidi?cation via inhibition of NHE1 in human colon cancer cells, Cancer Res. 67 (2007) 7865-7874.
  59. S. Yehuda, S. Rabinovitz, R.L. Carasso, D.I. Mostofsky, The role of polyunsaturated fatty acids in restoring the aging neuronal membrane, Neurobiol. Aging 23 (2002) 843-853.
  60. F.M. Goñi, Non-permanent proteins in membranes: when proteins come as visitors (review), Mol. Membr. Biol. 19 (2002) 237-245.
  61. Holzer, E.J. Park, N. Li, H. Tran, M. Chen, C. Choi, G. Solinas, M. Karin, Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation, Cell 147 (2011) 173-184.
  62. A. Jaeschke, R.J. Davis, Metabolic stress signaling mediated by mixed-lineage kinases, Mol. Cell. 27 (2007) 498-508.
  63. L. Vigh, B. Maresca, J.L. Harwood, Does the membrane's physical state control the expression of heat shock and other genes? Trends Biochem. Sci. 23 (1998) 369-374.
  64. L. Vigh, I. Horvath, B. Maresca, J.L. Harwood, Can the stress protein response be controlled by ‘membrane-lipid therapy’? Trends Biochem. Sci. 32 (2007) 357-363.
  65. V. Foulon, M. Sniekers, E. Huysmans, S. Asselberghs, V. Mahieu, G.P. Mannaerts, P.P. Van Veldhoven, M. Casteels, Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids, J. Biol. Chem. 280 (2005) 9802-9812.