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Plant-Derived Polyphenols in Human Health: Biological Activity, Metabolites and Putative Molecular Targets. Olivares-Vicente, M., Barrajón-Catalán, E., Herranz-López, M., Segura-Carretero, A., Joven, J., Encinar, J.A.and Micol, V. 2018. Current Drug Metabolism.

  1. Duthie, G. G.; Gardner, P. T.; Kyle, J. A., Plant polyphenols: are they the new magic bullet? Proc. Nutr. Soc. 2003, 62 (3), 599-603.
  2. Whiting, D. A., Natural phenolic compounds 1900-2000: a bird's eye view of a century's chemistry. Nat. Prod. Rep. 2001, 18 (6), 583-606.
  3. Manach, C.; Scalbert, A.; Morand, C.; Remesy, C.; Jimenez, L., Polyphenols: food sources and bioavailability. Am. J. Clin. Nutr. 2004, 79 (5), 727-47.
  4. Manach, C.; Williamson, G.; Morand, C.; Scalbert, A.; Remesy, C., Bioavailability and bioefficacy of polyphenols in humans. I. Review. of 97 bioavailability studies. Am. J. Clin. Nutr. 2005, 81 (1 Suppl), 230s-242s.
  5. Scalbert, A.; Williamson, G., Dietary intake and bioavailability of polyphenols. J. Nutr. 2000, 130 (8S Suppl), 2073s-85s.
  6. Mukhtar, H.; Ahmad, N., Tea polyphenols: prevention of cancer and optimizing health. Am. J. Clin. Nutr. 2000, 71 (6 Suppl), 1698S-702S; discussion 1703S-4S.
  7. Barrajon-Catalan, E.; Fernandez-Arroyo, S.; Saura, D.; Guillen, E.; Fernandez-Gutierrez, A.; Segura-Carretero, A.; Micol, V., Cistaceae aqueous extracts containing ellagitannins show antioxidant and antimicrobial capacity, and cytotoxic activity against human cancer cells. Food Chem. Toxicol. 2010, 48 (8-9), 2273-82.
  8. Loke, W. M.; Proudfoot, J. M.; Hodgson, J. M.; McKinley, A. J.; Hime, N.; Magat, M.; Stocker, R.; Croft, K. D., Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction. Arterioscler. Thromb. Vasc. Biol. 2010, 30 (4), 749-57.
  9. Daglia, M., Polyphenols as antimicrobial agents. Curr. Opin. Biotech. 2012, 23 (2), 174–181.
  10. Negishi, H.; Xu, J. W.; Ikeda, K.; Njelekela, M.; Nara, Y.; Yamori, Y., Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats. J. Nutr. 2004, 134 (1), 38-42.
  11. Vendrame, S.; Klimis-Zacas, D., Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-kappaB and mitogenactivated protein kinase signaling cascades. Nutr. Rev. 2015, 73 (6), 348-58.
  12. Li, A. N.; Li, S.; Zhang, Y. J.; Xu, X. R.; Chen, Y. M.; Li, H. B., Resources and biological activities of natural polyphenols. Nutrients 2014, 6 (12), 6020-47.
  13. Beltran-Debon, R.; Rull, A.; Rodriguez-Sanabria, F.; Iswaldi, I.; Herranz-Lopez, M.; Aragones, G.; Camps, J.; Alonso-Villaverde, C.; Menendez, J. A.; Micol, V.; Segura-Carretero, A.; Joven, J., Continuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice. Phytomedicine 2011, 18 (5), 414-24.
  14. Barrajon-Catalan, E.; Herranz-Lopez, M.; Joven, J.; Segura-Carretero, A.; Alonso-Villaverde, C.; Menendez, J. A.; Micol, V., Molecular promiscuity of plant polyphenols in the management of age-related diseases: far beyond their antioxidant properties. Adv. Exp. Med. Biol. 2014, 824, 141-59.
  15. Fernandez-Arroyo, S.; Herranz-Lopez, M.; Beltran-Debon, R.; Borras-Linares, I.; Barrajon-Catalan, E.; Joven, J.; Fernandez-Gutierrez, A.; Segura-Carretero, A.; Micol, V., Bioavailability study of a polyphenol-enriched extract from Hibiscus sabdariffa in rats and associated antioxidant status. Mol. Nutr. Food. Res. 2012, 56 (10), 1590-5.
  16. Quirantes-Pine, R.; Herranz-Lopez, M.; Funes, L.; Borras-Linares, I.; Micol, V.; Segura-Carretero, A.; Fernandez-Gutierrez, A., Phenylpropanoids and their metabolites are the major compounds responsible for blood-cell protection against oxidative stress after administration of Lippia citriodora in rats. Phytomedicine 2013, 20 (12), 1112-8.
  17. Cassidy, A.; Brown, J. E.; Hawdon, A.; Faughnan, M. S.; King, L. J.; Millward, J.; Zimmer-Nechemias, L.; Wolfe, B.; Setchell, K. D., Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods. J. Nutr. 2006, 136 (1), 45-51.
  18. Joven, J.; Micol, V.; Segura-Carretero, A.; Alonso-Villaverde, C.; Menéndez, J. A.; Aragonès, G.; Barrajón-Catalán, E.; Beltrán-Debón, R.; Camps, J.; Cufí, S.; Fernández-Arroyo, S.; Fernández-Gutiérrez, A.; Guillén, E.; Herranz-López, M.; Iswaldi, I.; Lozano-Sánchez, J.; Martin-Castillo, B.; Oliveras-Ferraros, C.; Pérez-Sánchez, A.; Rodríguez-Gallego, E.; Rull, A.; Saura, D.; Vázquez-Martín, A., Polyphenols and the Modulation of Gene Expression Pathways: Can We Eat Our Way Out of the Danger of Chronic Disease? Crit. Rev. Food Sci. Nutr. 2014, 54 (8), 985-1001.
  19. Morton, J. F., Roselle. Hibiscus sabdariffa L. Fruits of Warm Climates. Julia F. Morton, Miami, FL, USA 1987, 281-86.
  20. Serban, C.; Sahebkar, A.; Ursoniu, S.; Andrica, F.; Banach, M., Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials. J. Hypertens. 2015, 33 (6), 1119-27.
  21. Joven, J.; March, I.; Espinel, E.; Fernandez-Arroyo, S.; Rodriguez-Gallego, E.; Aragones, G.; Beltran-Debon, R.; Alonso-Villaverde, C.; Rios, L.; Martin-Paredero, V.; Menendez, J. A.; Micol, V.; Segura-Carretero, A.; Camps, J., Hibiscus sabdariffa extract lowers blood pressure and improves endothelial function. Mol. Nutr. Food. Res. 2014, 58 (6), 1374-8.
  22. Reanmongkol, W.; Itharat, A., Antipyretic activity of the extracts of Hibiscus sabdariffa calyces L. in experimental animals. Songklanakarin J. Sci. Technol. 2007, 29 (1), 29-38.
  23. Beltran-Debon, R.; Alonso-Villaverde, C.; Aragones, G.; Rodriguez-Medina, I.; Rull, A.; Micol, V.; Segura-Carretero, A.; Fernandez-Gutierrez, A.; Camps, J.; Joven, J., The aqueous extract of Hibiscus sabdariffa calices modulates the production of monocyte chemoattractant protein-1 in humans. Phytomedicine 2010, 17 (3-4), 186-91.
  24. Chou, S. T.; Lo, H. Y.; Li, C. C.; Cheng, L. C.; Chou, P. C.; Lee, Y. C.; Ho, T. Y.; Hsiang, C. Y., Exploring the effect and mechanism of Hibiscus sabdariffa on urinary tract infection and experimental renal inflammation. J. Ethnopharmacol. 2016, 194, 617-625.
  25. Seujange, Y.; Leelahavanichkul, A.; Yisarakun, W.; Khawsuk, W.; Meepool, A.; Phamonleatmongkol, P.; Saechau, W.; Onlamul, W.; Tantiwarattanatikul, P.; Oonsook, W.; Eiam-Ong, S., Hibiscus sabdariffa Linnaeus aqueous extracts attenuate the progression of renal injury in 5/6 nephrectomy rats. Ren. Fail. 2013, 35 (1), 118-25.
  26. Villalpando-Arteaga, E. V.; Mendieta-Condado, E.; Esquivel-Solis, H.; Canales-Aguirre, A. A.; Galvez-Gastelum, F. J.; Mateos-Diaz, J. C.; Rodriguez-Gonzalez, J. A.; Marquez-Aguirre, A. L., Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-gamma and SREBP-1c in diet-induced obese mice. Food Funct. 2013, 4 (4), 618-26.
  27. Adeyemi, D. O.; Ukwenya, V. O.; Obuotor, E. M.; Adewole, S. O., Anti-hepatotoxic activities of Hibiscus sabdariffa L. in animal model of streptozotocin diabetes-induced liver damage. BMC Complement. Altern. Med. 2014, 14, 277.
  28. Joven, J.; Espinel, E.; Rull, A.; Aragones, G.; Rodriguez-Gallego, E.; Camps, J.; Micol, V.; Herranz-Lopez, M.; Menendez, J. A.; Borras, I.; Segura-Carretero, A.; Alonso-Villaverde, C.; Beltran-Debon, R., Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent dietinduced fatty liver disease in hyperlipidemic mice. Biochim. Biophys. Acta 2012, 1820 (7), 894-9.
  29. Chang, H. C.; Peng, C. H.; Yeh, D. M.; Kao, E. S.; Wang, C. J., Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans. Food. Funct. 2014, 5 (4), 734-9.
  30. Alarcon-Aguilar, F. J.; Zamilpa, A.; Perez-Garcia, M. D.; Almanza-Perez, J. C.; Romero-Nunez, E.; Campos-Sepulveda, E. A.; Vazquez-Carrillo, L. I.; Roman-Ramos, R., Effect of Hibiscus sabdariffa on obesity in MSG mice. J. Ethnopharmacol. 2007, 114 (1), 66-71.
  31. Fernandez-Arroyo, S.; Rodriguez-Medina, I.; Beltran-Debon, R.; Pasini, F.; Joven, J.; Micol, V.; Segura-Carretero, A.; Fernandez-Gutierrez, A., Quantification of the polyphenolic fraction and in vitro antioxidant and in vivo anti-hyperlipemic activities of Hibiscus sabdariffa aqueous extract. Food Res. Int. 2011, 44 (5), 1490-95.
  32. Zhen, J.; Villani, T. S.; Guo, Y.; Qi, Y.; Chin, K.; Pan, M. H.; Ho, C. T.; Simon, J. E.; Wu, Q., Phytochemistry, antioxidant capacity, total phenolic content and anti-inflammatory activity of Hibiscus sabdariffa leaves. Food Chem. 2016, 190, 673-80.
  33. Herranz-Lopez, M.; Fernandez-Arroyo, S.; Perez-Sanchez, A.; Barrajon-Catalan, E.; Beltran-Debon, R.; Menendez, J. A.; Alonso-Villaverde, C.; Segura-Carretero, A.; Joven, J.; Micol, V., Synergism of plant-derived polyphenols in adipogenesis: perspectives and implications. Phytomedicine 2012, 19 (3-4), 253-61.
  34. Malacrida, A.; Maggioni, D.; Cassetti, A.; Nicolini, G.; Cavaletti, G.; Miloso, M., Antitumoral Effect of Hibiscus sabdariffa on Human Squamous Cell Carcinoma and Multiple Myeloma Cells. Nutr. Cancer 2016, 68 (7), 1161-70.
  35. Chen, C. C.; Hsu, J. D.; Wang, S. F.; Chiang, H. C.; Yang, M. Y.; Kao, E. S.; Ho, Y. C.; Wang, C. J., Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J. Agric. Food. Chem. 2003, 51 (18), 5472-7.
  36. Chang, Y. C.; Huang, K. X.; Huang, A. C.; Ho, Y. C.; Wang, C. J., Hibiscus anthocyanins-rich extract inhibited LDL oxidation and oxLDL-mediated macrophages apoptosis. Food Chem. Toxicol. 2006, 44 (7), 1015-23.
  37. Hassan, S. T.; Berchova, K.; Sudomova, M., Antimicrobial, antiparasitic and anticancer properties of Hibiscus sabdariffa (L.) and its phytochemicals: in vitro and in vivo studies. Ceska Slov. Farm. 2016, 65 (1), 10-4.
  38. Rodriguez-Medina, I. C.; Beltran-Debon, R.; Molina, V. M.; Alonso-Villaverde, C.; Joven, J.; Menendez, J. A.; Segura-Carretero, A.; Fernandez-Gutierrez, A., Direct characterization of aqueous extract of Hibiscus sabdariffa using HPLC with diode array detection coupled to ESI and ion trap MS. J. Sep. Sci. 2009, 32 (20), 3441-8.
  39. Muller, B. M.; Franz, G., Chemical structure and biological activity of polysaccharides from Hibiscus sabdariffa. Planta Med. 1992, 58 (1), 60-7.
  40. Kao, E. S.; Hsu, J. D.; Wang, C. J.; Yang, S. H.; Cheng, S. Y.; Lee, H. J., Polyphenols extracted from Hibiscus sabdariffa L. inhibited lipopolysaccharide-induced inflammation by improving antioxidative conditions and regulating cyclooxygenase-2 expression. Biosci. Biotechnol. Biochem. 2009, 73 (2), 385-90.
  41. Herrera-Arellano, A.; Miranda-Sanchez, J.; Avila-Castro, P.; Herrera-Alvarez, S.; Jimenez-Ferrer, J. E.; Zamilpa, A.; Roman-Ramos, R.; Ponce-Monter, H.; Tortoriello, J., Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial. Planta Med. 2007, 73 (1), 6-12.
  42. Nwachukwu, D. C.; Aneke, E.; Nwachukwu, N. Z.; Obika, L. F.; Nwagha, U. I.; Eze, A. A., Effect of Hibiscus sabdariffa on blood pressure and electrolyte profile of mild to moderate hypertensive Nigerians: A comparative study with hydrochlorothiazide. Niger J. Clin. Pract. 2015, 18 (6), 762-70.
  43. Ajiboye, T. O.; Raji, H. O.; Adeleye, A. O.; Adigun, N. S.; Giwa, O. B.; Ojewuyi, O. B.; Oladiji, A. T., Hibiscus sabdariffa calyx palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in fructose-induced metabolic syndrome rats. J. Sci. Food Agric. 2016, 96 (5), 1522-31.
  44. Gurrola-Diaz, C. M.; Garcia-Lopez, P. M.; Sanchez-Enriquez, S.; Troyo-Sanroman, R.; Andrade-Gonzalez, I.; Gomez-Leyva, J. F., Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy). Phytomedicine 2010, 17 (7), 500-5.
  45. Frank, T.; Janssen, M.; Netzel, M.; Strass, G.; Kler, A.; Kriesl, E.; Bitsch, I., Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. J. Clin. Pharmacol. 2005, 45 (2), 203-10.
  46. Borras-Linares, I.; Herranz-Lopez, M.; Barrajon-Catalan, E.; Arraez-Roman, D.; Gonzalez-Alvarez, I.; Bermejo, M.; Fernandez Gutierrez, A.; Micol, V.; Segura-Carretero, A., Permeability Study of Polyphenols Derived from a phenolic-enriched Hibiscus sabdariffa extract by UHPLC-ESI-UHR-Qq-TOF-MS. Int. J. Mol. Sci. 2015, 16 (8), 18396-411.
  47. del Mar Contreras, M.; Borrás-Linares, I.; Herranz-López, M.; Micol, V.; Segura-Carretero, A., Further exploring the absorption and enterocyte metabolism of quercetin forms in the Caco-2 model using nano-LC-TOF-MS. Electrophoresis 2016, 37 (7-8), 998-1006.
  48. Herranz-López, M.; Borrás-Linares, I.; Olivares-Vicente, M.; Gálvez, J.; Segura-Carretero, A.; Micol, V., Correlation between the cellular metabolism of quercetin and its glucuronide metabolite and oxidative stress in hypertrophied 3T3-L1 adipocytes. Phytomedicine 2017, 25, 25–28.
  49. Frank, T.; Netzel, G.; Kammerer, D. R.; Carle, R.; Kler, A.; Kriesl, E.; Bitsch, I.; Bitsch, R.; Netzel, M., Consumption of Hibiscus sabdariffa L. aqueous extract and its impact on systemic antioxidant potential in healthy subjects. J. Sci. Food Agric. 2012, 92 (10), 2207-18.
  50. Akindahunsi, A. A.; Olaleye, M. T., Toxicological investigation of aqueous-methanolic extract of the calyces of Hibiscus sabdariffa L. J. Ethnopharmacol. 2003, 89 (1), 161-4.
  51. Fakeye, T. O.; Pal, A.; Bawankule, D. U.; Yadav, N. P.; Khanuja, S. P., Toxic effects of oral administration of extracts of dried calyx of Hibiscus sabdariffa Linn. (Malvaceae). Phytother. Res. 2009, 23 (3), 412-6.
  52. Sireeratawong, S.; Itharat, A.; Khonsung, P.; Lertprasertsuke, N.; Jaijoy, K., Toxicity studies of the water extract from the calyces of Hibiscus sabdariffa L. in rats. Afr. J. Tradit. Complement. Altern. Med. 2013, 10 (4), 122-7.
  53. Argyropoulou, C.; Daferera, D.; Tarantilis, P. A.; Fasseas, C.; Polissiou, M., Chemical composition of the essential oil from leaves of Lippia citriodora H.B.K. (Verbenaceae) at two developmental stages. Biochem. Syst. Ecol. 2007, 35 (12), 831–837.
  54. Bilia, A. R.; Giomi, M.; Innocenti, M.; Gallori, S.; Vincieri, F. F., HPLC-DAD-ESI-MS analysis of the constituents of aqueous preparations of verbena and lemon verbena and evaluation of the antioxidant activity. J. Pharm. Biomed. Anal. 2008, 46 (3), 463-70.
  55. Funes, L.; Fernández-Arroyo, S.; Laporta, O.; Pons, A.; Roche, E.; Segura-Carretero, A.; Fernández-Gutiérrez, A.; Micol, V., Correlation between plasma antioxidant capacity and verbascoside levels in rats after oral administration of lemon verbena extract. Food Chem. 2009, 117 (4), 589–598.
  56. Liu, M. J.; Li, J. X.; Guo, H. Z.; Lee, K. M.; Qin, L.; Chan, K. M., The effects of verbascoside on plasma lipid peroxidation level and erythrocyte membrane fluidity during immobilization in rabbits: a time course study. Life Sci. 2003, 73 (7), 883-92.
  57. Wong, I. Y.; He, Z. D.; Huang, Y.; Chen, Z. Y., Antioxidative activities of phenylethanoid glycosides from Ligustrum purpurascens. J. Agric. Food. Chem. 2001, 49 (6), 3113-9.
  58. Quirantes-Pine, R.; Funes, L.; Micol, V.; Segura-Carretero, A.; Fernandez-Gutierrez, A., High-performance liquid chromatography with diode array detection coupled to electrospray time-of-flight and ion-trap tandem mass spectrometry to identify phenolic compounds from a lemon verbena extract. J. Chromatogr. A 2009, 1216 (28), 5391-7.
  59. Quirantes-Pine, R.; Arraez-Roman, D.; Segura-Carretero, A.; Fernandez-Gutierrez, A., Characterization of phenolic and other polar compounds in a lemon verbena extract by capillary electrophoresiselectrospray ionization-mass spectrometry. J. Sep. Sci. 2010, 33 (17-18), 2818-27.
  60. Pascual, M. E.; Slowing, K.; Carretero, E.; Sanchez Mata, D.; Villar, A., Lippia: traditional uses, chemistry and pharmacology: a review. J Ethnopharmacol. 2001, 76 (3), 201-14.
  61. Diaz, A. M.; Abad, M. J.; Fernandez, L.; Silvan, A. M.; De Santos, J.; Bermejo, P., Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity. Life Sci. 2004, 74 (20), 2515-26.
  62. Avila, J. G.; de Liverant, J. G.; Martinez, A.; Martinez, G.; Munoz, J. L.; Arciniegas, A.; Romo de Vivar, A., Mode of action of Buddleja cordata verbascoside against Staphylococcus aureus. J Ethnopharmacol. 1999, 66 (1), 75-8.
  63. Ohno, T.; Inoue, M.; Ogihara, Y.; Saracoglu, I., Antimetastatic activity of acteoside, a phenylethanoid glycoside. Biol. Pharm. Bull. 2002, 25 (5), 666-8.
  64. Funes, L.; Laporta, O.; Cerdán-Calero, M.; Micol, V., Effects of verbascoside, a phenylpropanoid glycoside from lemon verbena, on phospholipid model membranes. Chem. Phys. Lipids 2010, 163 (2), 190-199.
  65. Herranz-López, M.; Barrajón-Catalán, E.; Segura-Carretero, A.; Menéndez, J. A.; Joven, J.; Micol, V., Lemon verbena (Lippia citriodora) polyphenols alleviate obesity-related disturbances in hypertrophic adipocytes through AMPK-dependent mechanisms. Phytomedicine 2015, 22 (6), 605-614.
  66. Wu, Y. T.; Lin, L. C.; Sung, J. S.; Tsai, T. H., Determination of acteoside in Cistanche deserticola and Boschniakia rossica and its pharmacokinetics in freely-moving rats using LC-MS/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2006, 844 (1), 89-95.
  67. Quirantes-Pine, R.; Verardo, V.; Arraez-Roman, D.; Fernandez-Arroyo, S.; Micol, V.; Caboni, M. F.; Segura-Carretero, A.; Fernandez-Gutierrez, A., Evaluation of different extraction approaches for the determination of phenolic compounds and their metabolites in plasma by nanoLC-ESI-TOF-MS. Anal. Bioanal. Chem. 2012, 404 (10), 3081-90.
  68. Felgines, C.; Fraisse, D.; Besson, C.; Vasson, M. P.; Texier, O., Bioavailability of lemon verbena (Aloysia triphylla) polyphenols in rats: impact of colonic inflammation. Br. J. Nutr. 2014, 111 (10), 1773-81.
  69. Funes, L.; Carrera-Quintanar, L.; Cerdan-Calero, M.; Ferrer, M. D.; Drobnic, F.; Pons, A.; Roche, E.; Micol, V., Effect of lemon verbena supplementation on muscular damage markers, proinflammatory cytokines release and neutrophils' oxidative stress in chronic exercise. Eur. J. Appl. Physiol. 2011, 111 (4), 695-705.
  70. Carrera-Quintanar, L.; Funes, L.; Viudes, E.; Tur, J.; Micol, V.; Roche, E.; Pons, A., Antioxidant effect of lemon verbena extracts in lymphocytes of university students performing aerobic training program. Scand. J. Med. Sci. Sports 2012, 22 (4), 454-61.
  71. Carrera-Quintanar, L.; Funes, L.; Vicente-Salar, N.; Blasco-Lafarga, C.; Pons, A.; Micol, V.; Roche, E., Effect of polyphenol supplements on redox status of blood cells: a randomized controlled exercise training trial. Eur. J. Nutr. 2015, 54 (7), 1081-93.
  72. Mestre-Alfaro, A.; Ferrer, M. D.; Sureda, A.; Tauler, P.; Martinez, E.; Bibiloni, M. M.; Micol, V.; Tur, J. A.; Pons, A., Phytoestrogens enhance antioxidant enzymes after swimming exercise and modulate sex hormone plasma levels in female swimmers. Eur. J. Appl. Physiol. 2011, 111 (9), 2281-94.
  73. Martinez-Rodriguez, A.; Moya, M.; Vicente-Salar, N.; Brouzet, T.; Carrera-Quintanar, L.; Cervello, E.; Micol, V.; Roche, E., Biochemical and psychological changes in university students performing aerobic exercise and consuming lemon verbena extracts. Curr. Top. Nutraceut. R. 2015, 13 (2), 95-102.
  74. Caturla, N.; Funes, L.; Perez-Fons, L.; Micol, V., A randomized, double-blinded, placebo-controlled study of the effect of a combination of lemon verbena extract and fish oil omega-3 fatty acid on joint management. J. Altern. Complement. Med. 2011, 17 (11), 1051-63.
  75. Mauriz, E.; Vallejo, D.; Tunon, M. J.; Rodriguez-Lopez, J. M.; Rodriguez-Perez, R.; Sanz-Gomez, J.; Garcia-Fernandez Mdel, C., Effects of dietary supplementation with lemon verbena extracts on serum inflammatory markers of multiple sclerosis patients. Nutr. Hosp. 2014, 31 (2), 764-71.
  76. Miroddi, M.; Calapai, G.; Isola, S.; Minciullo, P. L.; Gangemi, S., Rosmarinus officinalis L. as cause of contact dermatitis. Allergol. Immunopathol. (Madr) 2014, 42 (6), 616-9.
  77. Troncoso, N.; Sierra, H.; Carvajal, L.; Delpiano, P.; Gunther, G., Fast high performance liquid chromatography and ultravioletvisible quantification of principal phenolic antioxidants in fresh rosemary. J. Chromatogr. A 2005, 1100 (1), 20-5.
  78. Peng, Y.; Yuan, J.; Liu, F.; Ye, J., Determination of active components in rosemary by capillary electrophoresis with electrochemical detection. J. Pharm. Biomed. Anal. 2005, 39 (3-4), 431-7.
  79. Perez-Fons, L.; Garzon, M. T.; Micol, V., Relationship between the antioxidant capacity and effect of rosemary (Rosmarinus officinalis L.) polyphenols on membrane phospholipid order. J. Agric. Food Chem. 2010, 58 (1), 161-71.
  80. Bai, N.; He, K.; Roller, M.; Lai, C. S.; Shao, X.; Pan, M. H.; Ho, C. T., Flavonoids and phenolic compounds from Rosmarinus officinalis. J. Agric. Food Chem. 2010, 58 (9), 5363-7.
  81. Hussain, A. I.; Anwar, F.; Chatha, S. A.; Jabbar, A.; Mahboob, S.; Nigam, P. S., Rosmarinus officinalis essential oil: antiproliferative, antioxidant and antibacterial activities. Braz. J. Microbiol. 2010, 41 (4), 1070-8.
  82. Borras-Linares, I.; Stojanovic, Z.; Quirantes-Pine, R.; Arraez-Roman, D.; Svarc-Gajic, J.; Fernandez-Gutierrez, A.; Segura-Carretero, A., Rosmarinus officinalis leaves as a natural source of bioactive compounds. Int. J. Mol. Sci. 2014, 15 (11), 20585-606.
  83. Mena, P.; Cirlini, M.; Tassotti, M.; Herrlinger, K. A.; Dall'Asta, C.; Del Rio, D., Phytochemical Profiling of Flavonoids, Phenolic Acids, Terpenoids, and Volatile Fraction of a Rosemary (Rosmarinus officinalis L.) Extract. Molecules 2016, 21 (11).
  84. Al-Attar, A. M.; Shawush, N. A., Influence of olive and rosemary leaves extracts on chemically induced liver cirrhosis in male rats. Saudi J. Biol. Sci. 2015, 22 (2), 157-63.
  85. Klancnik, A.; Guzej, B.; Kolar, M. H.; Abramovic, H.; Mozina, S. S., In vitro antimicrobial and antioxidant activity of commercial rosemary extract formulations. J. Food Prot. 2009, 72 (8), 1744-52.
  86. Chae, I. G.; Yu, M. H.; Im, N. K.; Jung, Y. T.; Lee, J.; Chun, K. S.; Lee, I. S., Effect of Rosemarinus officinalis L. on MMP-9, MCP-1 levels, and cell migration in RAW 264.7 and smooth muscle cells. J. Med. Food 2012, 15 (10), 879-86.
  87. Ramadan, K. S.; Khalil, O. A.; Danial, E. N.; Alnahdi, H. S.; Ayaz, N. O., Hypoglycemic and hepatoprotective activity of Rosmarinus officinalis extract in diabetic rats. J. Physiol. Biochem. 2013, 69 (4), 779-83.
  88. Martinez, A. L.; Gonzalez-Trujano, M. E.; Chavez, M.; Pellicer, F., Antinociceptive effectiveness of triterpenes from rosemary in visceral nociception. J. Ethnopharmacol. 2012, 142 (1), 28-34.
  89. Takaki, I.; Bersani-Amado, L. E.; Vendruscolo, A.; Sartoretto, S. M.; Diniz, S. P.; Bersani-Amado, C. A.; Cuman, R. K., Antiinflammatory and antinociceptive effects of Rosmarinus officinalis L. essential oil in experimental animal models. J. Med. Food 2008, 11 (4), 741-6.
  90. Rocha, J.; Eduardo-Figueira, M.; Barateiro, A.; Fernandes, A.; Brites, D.; Bronze, R.; Duarte, C. M.; Serra, A. T.; Pinto, R.; Freitas, M.; Fernandes, E.; Silva-Lima, B.; Mota-Filipe, H.; Sepodes, B., Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation. Basic Clin. Pharmacol. Toxicol. 2015, 116 (5), 398-413.
  91. Medicherla, K.; Ketkar, A.; Sahu, B. D.; Sudhakar, G.; Sistla, R., Rosmarinus officinalis L. extract ameliorates intestinal inflammation through MAPKs/NF-kappaB signaling in a murine model of acute experimental colitis. Food Funct. 2016, 7 (7), 3233-43.
  92. Gonzalez-Vallinas, M.; Molina, S.; Vicente, G.; Zarza, V.; Martin-Hernandez, R.; Garcia-Risco, M. R.; Fornari, T.; Reglero, G.; Ramirez de Molina, A., Expression of microRNA-15b and the glycosyltransferase GCNT3 correlates with antitumor efficacy of Rosemary diterpenes in colon and pancreatic cancer. PLoS One 2014, 9 (6), e98556.
  93. Scheckel, K. A.; Degner, S. C.; Romagnolo, D. F., Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. J. Nutr. 2008, 138 (11), 2098-105.
  94. Moreno, S.; Scheyer, T.; Romano, C. S.; Vojnov, A. A., Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition. Free Radic. Res. 2006, 40 (2), 223-31.
  95. Zeng, H. H.; Tu, P. F.; Zhou, K.; Wang, H.; Wang, B. H.; Lu, J. F., Antioxidant properties of phenolic diterpenes from Rosmarinus officinalis. Acta Pharmacol. Sin. 2001, 22 (12), 1094-8.
  96. Yesil-Celiktas, O.; Sevimli, C.; Bedir, E.; Vardar-Sukan, F., Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines. Plant Foods Hum. Nutr. 2010, 65 (2), 158-63.
  97. Barni, M. V.; Carlini, M. J.; Cafferata, E. G.; Puricelli, L.; Moreno, S., Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells. Oncol. Rep. 2012, 27 (4), 1041-8.
  98. Gonzalez-Vallinas, M.; Molina, S.; Vicente, G.; Sanchez-Martinez, R.; Vargas, T.; Garcia-Risco, M. R.; Fornari, T.; Reglero, G.; Ramirez de Molina, A., Modulation of estrogen and epidermal growth factor receptors by rosemary extract in breast cancer cells. Electrophoresis 2014, 35 (11), 1719-27.
  99. Valdes, A.; Garcia-Canas, V.; Simo, C.; Ibanez, C.; Micol, V.; Ferragut, J. A.; Cifuentes, A., Comprehensive foodomics study on the mechanisms operating at various molecular levels in cancer cells in response to individual rosemary polyphenols. Anal. Chem. 2014, 86 (19), 9807-15.
  100. Borras-Linares, I.; Perez-Sanchez, A.; Lozano-Sanchez, J.; Barrajon-Catalan, E.; Arraez-Roman, D.; Cifuentes, A.; Micol, V.; Carretero, A. S., A bioguided identification of the active compounds that contribute to the antiproliferative/cytotoxic effects of rosemary extract on colon cancer cells. Food Chem Toxicol 2015, 80, 215-22.
  101. Richheimer, S. L.; Bernart, M. W.; King; A., G.; Kent, M. C.; Beiley, D. T., Antioxidant activity of lipid-soluble phenolic diterpenes from rosemary. J. Am. Oil Chem. Soc. 1996, 73 (4), 507-14.
  102. Zhang, Y.; Chen, X.; Yang, L.; Zu, Y.; Lu, Q., Effects of rosmarinic acid on liver and kidney antioxidant enzymes, lipid peroxidation and tissue ultrastructure in aging mice. Food Funct. 2015, 6 (3), 927-31.
  103. Afonso, M. S.; de, O. S. A. M.; Carvalho, E. B.; Rivelli, D. P.; Barros, S. B.; Rogero, M. M.; Lottenberg, A. M.; Torres, R. P.; Mancini-Filho, J., Phenolic compounds from Rosemary (Rosmarinus officinalis L.) attenuate oxidative stress and reduce blood cholesterol concentrations in diet-induced hypercholesterolemic rats. Nutr. Metab. (Lond) 2013, 10 (1), 19.
  104. Hassani, F. V.; Shirani, K.; Hosseinzadeh, H., Rosemary (Rosmarinus officinalis) as a potential therapeutic plant in metabolic syndrome: a review. Naunyn Schmiedebergs Arch. Pharmacol. 2016, 389 (9), 931-49.
  105. Doolaege, E. H.; Raes, K.; De Vos, F.; Verhe, R.; De Smet, S., Absorption, distribution and elimination of carnosic acid, a natural antioxidant from Rosmarinus officinalis, in rats. Plant. Foods Hum. Nutr. 2011, 66 (2), 196-202.
  106. Romo Vaquero, M.; Garcia Villalba, R.; Larrosa, M.; Yanez-Gascon, M. J.; Fromentin, E.; Flanagan, J.; Roller, M.; Tomas-Barberan, F. A.; Espin, J. C.; Garcia-Conesa, M. T., Bioavailability of the major bioactive diterpenoids in a rosemary extract: metabolic profile in the intestine, liver, plasma, and brain of Zucker rats. Mol. Nut. Food Res. 2013, 57 (10), 1834-46.
  107. Perez-Sanchez, A.; Borras-Linares, I.; Barrajon-Catalan, E.; Arraez-Roman, D.; Gonzalez-Alvarez, I.; Ibanez, E.; Segura-Carretero, A.; Bermejo, M.; Micol, V., Evaluation of the intestinal permeability of rosemary (Rosmarinus officinalis L.) extract polyphenols and terpenoids in Caco-2 cell monolayers. PLoS ONE 2017, 12 (2), e0172063.
  108. Anadon, A.; Martinez-Larranaga, M. R.; Martinez, M. A.; Ares, I.; Garcia-Risco, M. R.; Senorans, F. J.; Reglero, G., Acute oral safety study of rosemary extracts in rats. J. Food Prot. 2008, 71 (4), 790-5.
  109. Nobile, V.; Michelotti, A.; Cestone, E.; Caturla, N.; Castillo, J.; Benavente-Garcia, O.; Perez-Sanchez, A.; Micol, V., Skin photoprotective and antiageing effects of a combination of rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradisi) polyphenols. Food Nut.r Res. 2016, 60, 31871.
  110. Grohmann, F., Oleaceae. Flora of West Pakistan. Karachi, Pakistan: University of Karachi 1974, 59, 9.
  111. Hashmi, M. A.; Khan, A.; Hanif, M.; Farooq, U.; Perveen, S., Traditional Uses, Phytochemistry, and Pharmacology of Olea europaea (Olive). Evid. Based Complement. Alternat. Med. 2015, 2015, 541591.
  112. Waterman, E.; Lockwood, B., Active components and clinical applications of olive oil. Altern. Med. Rev. 2007, 12 (4), 331-42.
  113. Wahrburg, U.; Kratz, M.; Cullen, P., Mediterranean diet, olive oil and health. Eur. J. Lipid Sci. Tech. 2002, 104 (2002), 698-705.
  114. Estruch, R.; Martinez-Gonzalez, M. A.; Corella, D.; Salas-Salvado, J.; Ruiz-Gutierrez, V.; Covas, M. I.; Fiol, M.; Gomez-Gracia, E.; Lopez-Sabater, M. C.; Vinyoles, E.; Aros, F.; Conde, M.; Lahoz, C.; Lapetra, J.; Saez, G.; Ros, E., Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann. Intern. Med. 2006, 145 (1), 1-11.
  115. Fito, M.; Guxens, M.; Corella, D.; Saez, G.; Estruch, R.; de la Torre, R.; Frances, F.; Cabezas, C.; Lopez-Sabater Mdel, C.; Marrugat, J.; Garcia-Arellano, A.; Aros, F.; Ruiz-Gutierrez, V.; Ros, E.; Salas-Salvado, J.; Fiol, M.; Sola, R.; Covas, M. I., Effect of a traditional Mediterranean diet on lipoprotein oxidation: a randomized controlled trial. Arch. Intern. Med. 2007, 167 (11), 1195-203.
  116. Scarmeas, N.; Luchsinger, J. A.; Mayeux, R.; Stern, Y., Mediterranean diet and Alzheimer disease mortality. Neurology 2007, 69 (11), 1084-93.
  117. Trichopoulou, A.; Costacou, T.; Bamia, C.; Trichopoulos, D., Adherence to a Mediterranean diet and survival in a Greek population. N. Engl. J. Med. 2003, 348 (26), 2599-608.
  118. Menendez, J. A.; Vazquez-Martin, A.; Oliveras-Ferraros, C.; Garcia-Villalba, R.; Carrasco-Pancorbo, A.; Fernandez-Gutierrez, A.; Segura-Carretero, A., Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays. Int. J. Mol. Med. 2008, 22 (4), 433-9.
  119. Menendez, J. A.; Vazquez-Martin, A.; Colomer, R.; Brunet, J.; Carrasco-Pancorbo, A.; Garcia-Villalba, R.; Fernandez-Gutierrez, A.; Segura-Carretero, A., Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells. BMC Cancer 2007, 7, 80.
  120. Menendez, J. A.; Joven, J.; Aragones, G.; Barrajon-Catalan, E.; Beltran-Debon, R.; Borras-Linares, I.; Camps, J.; Corominas-Faja, B.; Cufi, S.; Fernandez-Arroyo, S.; Garcia-Heredia, A.; Hernandez-Aguilera, A.; Herranz-Lopez, M.; Jimenez-Sanchez, C.; Lopez-Bonet, E.; Lozano-Sanchez, J.; Luciano-Mateo, F.; Martin-Castillo, B.; Martin-Paredero, V.; Perez-Sanchez, A.; Oliveras-Ferraros, C.; Riera-Borrull, M.; Rodriguez-Gallego, E.; Quirantes-Pine, R.; Rull, A.; Tomas-Menor, L.; Vazquez-Martin, A.; Alonso-Villaverde, C.; Micol, V.; Segura-Carretero, A., Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: A new family of gerosuppressant agents. Cell Cycle 2013, 12 (4), 555-78.
  121. de Bock, M.; Thorstensen, E. B.; Derraik, J. G.; Henderson, H. V.; Hofman, P. L.; Cutfield, W. S., Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract. Mol. Nutr. Food Res. 2013, 57 (11), 2079-85.
  122. Quirantes-Pine, R.; Lozano-Sanchez, J.; Herrero, M.; Ibanez, E.; Segura-Carretero, A.; Fernandez-Gutierrez, A., HPLC-ESI-QTOFMS as a powerful analytical tool for characterising phenolic compounds in olive-leaf extracts. Phytochem. Anal. 2013, 24 (3), 213-23.
  123. Savournin, C.; Baghdikian, B.; Elias, R.; Dargouth-Kesraoui, F.; Boukef, K.; Balansard, G., Rapid high-performance liquid chromatography analysis for the quantitative determination of oleuropein in Olea europaea leaves. J. Agric. Food Chem. 2001, 49 (2), 618-21.
  124. Tovar, M. J.; Motilva, M. J.; Romero, M. P., Changes in the phenolic composition of virgin olive oil from young trees (Olea europaea L. cv. Arbequina) grown under linear irrigation strategies. J. Agric. Food Chem. 2001, 49 (11), 5502-8.
  125. Campeol, E.; Flamini, G.; Cioni, P. L.; Morelli, I.; Cremonini, R.; Ceccarini, L., Volatile fractions from three cultivars of Olea europaea L. collected in two different seasons. J. Agric. Food Chem. 2003, 51 (7), 1994-9.
  126. Perez-Bonilla, M.; Salido, S.; van Beek, T. A.; Linares-Palomino, P. J.; Altarejos, J.; Nogueras, M.; Sanchez, A., Isolation and identification of radical scavengers in olive tree (Olea europaea) wood. J. Chromatogr. A 2006, 1112 (1-2), 311-8.
  127. Fu, S.; Arraez-Roman, D.; Segura-Carretero, A.; Menendez, J. A.; Menendez-Gutierrez, M. P.; Micol, V.; Fernandez-Gutierrez, A., Qualitative screening of phenolic compounds in olive leaf extracts by hyphenated liquid chromatography and preliminary evaluation of cytotoxic activity against human breast cancer cells. Anal. Bioanal. Chem. 2010, 397 (2), 643-54.
  128. Briante, R.; Patumi, M.; Terenziani, S.; Bismuto, E.; Febbraio, F.; Nucci, R., Olea europaea L. leaf extract and derivatives: antioxidant properties. J. Agric. Food Chem. 2002, 50 (17), 4934-40.
  129. Ammar, S.; Contreras, M. D.; Gargouri, B.; Segura-Carretero, A.; Bouaziz, M., RP-HPLC-DAD-ESI-QTOF-MS based metabolic profiling of the potential Olea europaea by-product "wood" and its comparison with leaf counterpart. Phytochem. Anal. 2017.
  130. Eidi, A.; Eidi, M.; Darzi, R., Antidiabetic effect of Olea europaea L. in normal and diabetic rats. Phytother. Res. 2009, 23 (3), 347-50.
  131. Al-Azzawie, H. F.; Alhamdani, M. S., Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. Life Sci. 2006, 78 (12), 1371-7.
  132. Khayyal, M. T.; el-Ghazaly, M. A.; Abdallah, D. M.; Nassar, N. N.; Okpanyi, S. N.; Kreuter, M. H., Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats. Arzneimittelforschung 2002, 52 (11), 797-802.
  133. Perrinjaquet-Moccetti, T.; Busjahn, A.; Schmidlin, C.; Schmidt, A.; Bradl, B.; Aydogan, C., Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother. Res. 2008, 22 (9), 1239-42.
  134. Eidi, A.; Moghadam-kia, S.; Moghadam, J. Z.; Eidi, M.; Rezazadeh, S., Antinociceptive and anti-inflammatory effects of olive oil (Olea europeae L.) in mice. Pharm. Biol. 2012, 50 (3), 332-7.
  135. Bouaziz, M.; Chamkha, M.; Sayadi, S., Comparative study on phenolic content and antioxidant activity during maturation of the olive cultivar Chemlali from Tunisia. J. Agric. Food Chem. 2004, 52 (17), 5476-81.
  136. Lee, O. H.; Lee, B. Y., Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract. Bioresour. Technol. 2010, 101 (10), 3751-4.
  137. Marchetti, C.; Clericuzio, M.; Borghesi, B.; Cornara, L.; Ribulla, S.; Gosetti, F.; Marengo, E.; Burlando, B., Oleuropein-enriched olive leaf extract affects calcium dynamics and impairs viability of malignant mesothelioma cells. Evid. Based Complement. Alternat. Med. 2015, 2015, 908493.
  138. Pereira, A. P.; Ferreira, I. C.; Marcelino, F.; Valentao, P.; Andrade, P. B.; Seabra, R.; Estevinho, L.; Bento, A.; Pereira, J. A., Phenolic compounds and antimicrobial activity of olive (Olea europaea L. Cv. Cobrancosa) leaves. Molecules 2007, 12 (5), 1153-62.
  139. Wainstein, J.; Ganz, T.; Boaz, M.; Bar Dayan, Y.; Dolev, E.; Kerem, Z.; Madar, Z., Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. J. Med. Food 2012, 15 (7), 605-10.
  140. Susalit, E.; Agus, N.; Effendi, I.; Tjandrawinata, R. R.; Nofiarny, D.; Perrinjaquet-Moccetti, T.; Verbruggen, M., Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine 2011, 18 (4), 251-8.
  141. Sudjana, A. N.; D'Orazio, C.; Ryan, V.; Rasool, N.; Ng, J.; Islam, N.; Riley, T. V.; Hammer, K. A., Antimicrobial activity of commercial Olea europaea (olive) leaf extract. Int. J. Antimicrob. Agents 2009, 33 (5), 461-3.
  142. Micol, V.; Caturla, N.; Perez-Fons, L.; Mas, V.; Perez, L.; Estepa, A., The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV). Antiviral Res. 2005, 66 (2-3), 129-36.
  143. Singh, I.; Mok, M.; Christensen, A. M.; Turner, A. H.; Hawley, J. A., The effects of polyphenols in olive leaves on platelet function. Nutr. Metab. Cardiovasc. Dis. 2008, 18 (2), 127-32.
  144. de la Puerta, R.; Ruiz Gutierrez, V.; Hoult, J. R., Inhibition of leukocyte 5-lipoxygenase by phenolics from virgin olive oil. Biochem. Pharmacol. 1999, 57 (4), 445-9.
  145. Carluccio, M. A.; Siculella, L.; Ancora, M. A.; Massaro, M.; Scoditti, E.; Storelli, C.; Visioli, F.; Distante, A.; De Caterina, R., Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler. Thromb. Vasc. Biol. 2003, 23 (4), 622-9.
  146. Acquaviva, R.; Di Giacomo, C.; Sorrenti, V.; Galvano, F.; Santangelo, R.; Cardile, V.; Gangia, S.; D'Orazio, N.; Abraham, N. G.; Vanella, L., Antiproliferative effect of oleuropein in prostate cell lines. Int J Oncol 2012, 41 (1), 31-8.
  147. Bisignano, G.; Tomaino, A.; Lo Cascio, R.; Crisafi, G.; Uccella, N.; Saija, A., On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol. J. Pharm. Pharmacol. 1999, 51 (8), 971-4.
  148. Perugini, P.; Vettor, M.; Rona, C.; Troisi, L.; Villanova, L.; Genta, I.; Conti, B.; Pavanetto, F., Efficacy of oleuropein against UVB irradiation: preliminary evaluation. Int. J. Cosmet. Sci. 2008, 30 (2), 113-20.
  149. Katsiki, M.; Chondrogianni, N.; Chinou, I.; Rivett, A. J.; Gonos, E. S., The olive constituent oleuropein exhibits proteasome stimulatory properties in vitro and confers life span extension of human embryonic fibroblasts. Rejuvenation Res. 2007, 10 (2), 157-72.
  150. Kruk, I.; Aboul-Enein, H. Y.; Michalska, T.; Lichszteld, K.; Kladna, A., Scavenging of reactive oxygen species by the plant phenols genistein and oleuropein. Luminescence 2005, 20 (2), 81-9.
  151. Caturla, N.; Perez-Fons, L.; Estepa, A.; Micol, V., Differential effects of oleuropein, a biophenol from Olea europaea, on anionic and zwiterionic phospholipid model membranes. Chem. Phys. Lipids 2005, 137 (1-2), 2-17.
  152. Corona, G.; Tzounis, X.; Assunta Dessi, M.; Deiana, M.; Debnam, E. S.; Visioli, F.; Spencer, J. P., The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation. Free Radic. Res. 2006, 40 (6), 647-58.
  153. Brenes, M.; Garcia, A.; Garcia, P.; Garrido, A., Acid hydrolysis of secoiridoid aglycons during storage of virgin olive oil. J Agric Food Chem 2001, 49 (11), 5609-14.
  154. Visioli, F.; Bellomo, G.; Galli, C., Free radical-scavenging properties of olive oil polyphenols. Biochem. Biophys. Res. Commun. 1998, 247 (1), 60-4.
  155. Visioli, F.; Galli, C.; Plasmati, E.; Viappiani, S.; Hernandez, A.; Colombo, C.; Sala, A., Olive phenol hydroxytyrosol prevents passive smoking-induced oxidative stress. Circulation 2000, 102 (18), 2169-71.
  156. Miro-Casas, E.; Covas, M. I.; Farre, M.; Fito, M.; Ortuno, J.; Weinbrenner, T.; Roset, P.; de la Torre, R., Hydroxytyrosol disposition in humans. Clin Chem 2003, 49 (6 Pt 1), 945-52.
  157. Kountouri, A. M.; Mylona, A.; Kaliora, A. C.; Andrikopoulos, N. K., Bioavailability of the phenolic compounds of the fruits (drupes) of Olea europaea (olives): impact on plasma antioxidant status in humans. Phytomedicine 2007, 14 (10), 659-67.
  158. Bazoti, F. N.; Gikas, E.; Tsarbopoulos, A., Simultaneous quantification of oleuropein and its metabolites in rat plasma by liquid chromatography electrospray ionization tandem mass spectrometry. Biomed. Chromatogr. 2010, 24 (5), 506-15.
  159. Vissers, M. N.; Zock, P. L.; Katan, M. B., Bioavailability and antioxidant effects of olive oil phenols in humans: a review. Eur. J. Clin. Nutr. 2004, 58 (6), 955-65.
  160. Rechner, A. R.; Kuhnle, G.; Hu, H.; Roedig-Penman, A.; van den Braak, M. H.; Moore, K. P.; Rice-Evans, C. A., The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites. Free Radic. Res. 2002, 36 (11), 1229-41.
  161. Garcia-Villalba, R.; Carrasco-Pancorbo, A.; Nevedomskaya, E.; Mayboroda, O. A.; Deelder, A. M.; Segura-Carretero, A.; Fernandez-Gutierrez, A., Exploratory analysis of human urine by LC-ESITOF MS after high intake of olive oil: understanding the metabolism of polyphenols. Anal. Bioanal. Chem. 2010, 398 (1), 463-75.
  162. Tuck, K. L.; Freeman, M. P.; Hayball, P. J.; Stretch, G. L.; Stupans, I., The in vivo fate of hydroxytyrosol and tyrosol, antioxidant phenolic constituents of olive oil, after intravenous and oral dosing of labeled compounds to rats. J. Nutr. 2001, 131 (7), 1993-6.
  163. Tuck, K. L.; Hayball, P. J.; Stupans, I., Structural characterization of the metabolites of hydroxytyrosol, the principal phenolic component in olive oil, in rats. J. Agric. Food Chem. 2002, 50 (8), 2404-9.
  164. Khymenets, O.; Fito, M.; Tourino, S.; Munoz-Aguayo, D.; Pujadas, M.; Torres, J. L.; Joglar, J.; Farre, M.; Covas, M. I.; de la Torre, R., Antioxidant activities of hydroxytyrosol main metabolites do not contribute to beneficial health effects after olive oil ingestion. Drug Metab. Dispos. 2010, 38 (9), 1417-21.
  165. Garcia-Villalba, R.; Larrosa, M.; Possemiers, S.; Tomas-Barberan, F. A.; Espin, J. C., Bioavailability of phenolics from an oleuropeinrich olive (Olea europaea) leaf extract and its acute effect on plasma antioxidant status: comparison between pre-and postmenopausal women. Eur. J. Nutr. 2014, 53 (4), 1015-27.
  166. Omer, S. A.; Elobeid, M. A.; Elamin, M. H.; Hassan, Z. K.; Virk, P.; Daghestani, M. H.; Al-Olayan, E. M.; Al-Eisa, N. A.; and Almarhoon, Z. M., Toxicity of Olive Leaves (Olea europaea L.) In Wistar Albino Rats. Asian J. Anim. Vet. Adv. 2012, 7 (11), 1175-82.
  167. Alecci, U.; Bonina, F.; Bonina, A.; Rizza, L.; Inferrera, S.; Mannucci, C.; Calapai, G., Efficacy and safety of a natural remedy for the treatment of gastroesophageal reflux: a double-blinded randomized-controlled study. Evid. Based Complement. Alternat. Med. 2016, 2016, 2581461.
  168. Clewell, A. E.; Beres, E.; Vertesi, A.; Glavits, R.; Hirka, G.; Endres, J. R.; Murbach, T. S.; Szakonyine, I. P., A comprehensive toxicological safety assessment of an extract of Olea europaea L. leaves (Bonolive). Intl Jl Toxicoll 2016, 35 (2), 208-21.
  169. Kanehisa, M.; Goto, S.; Sato, Y.; Kawashima, M.; Furumichi, M.; Tanabe, M., Data, information, knowledge and principle: back to metabolism in KEGG. Nucleic Acids Res. 2014, 42 (Database issue), D199-205.
  170. McKnight, S. L., On getting there from here. Science 2010, 330 (6009), 1338-9.
  171. Harvey, A. L.; Edrada-Ebel, R.; Quinn, R. J., The re-emergence of natural products for drug discovery in the genomics era. Nature reviews. Drug discovery 2015, 14 (2), 111-29.
  172. Gupta, S.; Aires-de-Sousa, J., Comparing the chemical spaces of metabolites and available chemicals: models of metabolitelikeness. Mol. Divers. 2007, 11 (1), 23-36.
  173. Forli, S.; Huey, R.; Pique, M. E.; Sanner, M. F.; Goodsell, D. S.; Olson, A. J., Computational protein-ligand docking and virtual drug screening with the AutoDock suite. Nat. Protoc. 2016, 11 (5), 905-19.
  174. Biasini, M.; Bienert, S.; Waterhouse, A.; Arnold, K.; Studer, G.; Schmidt, T.; Kiefer, F.; Gallo Cassarino, T.; Bertoni, M.; Bordoli, L.; Schwede, T., SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information. Nucleic Acids Res. 2014, 42 (Web Server issue), W252-8.
  175. Banerjee, P.; Erehman, J.; Gohlke, B. O.; Wilhelm, T.; Preissner, R.; Dunkel, M., Super Natural II--a database of natural products. Nucleic Acids Res. 2015, 43 (Database issue), D935-9.
  176. Trott, O.; Olson, A. J., AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J. Comput Chem. 2010, 31 (2), 455-61.
  177. Perez-Sanchez, H.; Wenzel, W., Optimization methods for virtual screening on novel computational architectures. Curr. Comput. Aided Drug Des. 2011, 7 (1), 44-52.
  178. Cheng, F.; Li, W.; Zhou, Y.; Shen, J.; Wu, Z.; Liu, G.; Lee, P. W.; Tang, Y., admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties. J. Chem. Inf. Model. 2012, 52 (11), 3099-105.
  179. Encinar, J. A.; Fernandez-Ballester, G.; Galiano-Ibarra, V.; Micol, V., In silico approach for the discovery of new PPARgamma modulators among plant-derived polyphenols. Drug design, development and therapy 2015, 9, 5877-95.
  180. Galiano, V.; Garcia-Valtanen, P.; Micol, V.; Encinar, J. A., Looking for inhibitors of the dengue virus NS5 RNA-dependent RNApolymerase using a molecular docking approach. Drug Des. Dev. Ther. 2016, 10, 3163-3181.
  181. Jimenez-Sanchez, C.; Olivares-Vicente, M.; Rodriguez-Perez, C.; Herranz-Lopez, M.; Lozano-Sanchez, J.; Segura-Carretero, A.; Fernandez-Gutierrez, A.; Encinar, J.A.; Micol, V. AMPK modulatory activity of olive-tree leaves phenolic compounds: Bioassay-guided isolation on adipocyte model and in silico approach. PLoS One 2017, 12, e0173074.
  182. Hardie, D. G., AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev. 2011, 25 (18), 1895-908.
  183. Riera-Borrull, M.; Rodriguez-Gallego, E.; Hernandez-Aguilera, A.; Luciano, F.; Ras, R.; Cuyas, E.; Camps, J.; Segura-Carretero, A.; Menendez, J. A.; Joven, J.; Fernandez-Arroyo, S., Exploring the process of energy generation in pathophysiology by targeted metabolomics: performance of a simple and quantitative method. J. Am. Soc. Mass Spectr. 2016, 27 (1), 168-77.
  184. Massucci, F. A.; Wheeler, J.; Beltran-Debon, R.; Joven, J.; Sales-Pardo, M.; Guimera, R., Inferring propagation paths for sparsely observed perturbations on complex networks. Science advances 2016, 2 (10), e1501638.