WO2022152800A1 TETRAHYDRO-SPIROINDOLINE-PYRROLOPYRROLE-TRIONES INHIBITORS OF THE NRF2-BETA-TRCP INTERACTION FOR USE IN THE TREATMENT OF FATTY LIVER DISEASE
By: Cuadrado Pastor, Antonio; Fernandez Gines, Raquel; Encinar, Jose Antonio; Leon Martinez, Rafael; Franco Gonzalez, Juan Felipe; Garcia Lopez, Manuela; Rodriguez Franco, Maria Isabel; Rojo Sanchis, Ana Isabel
World Intellectual Property Organization, WO2022152800 A1 2022-07-21 | Language: English
The present invention relates to NRF2-betaTrCP interaction inhibitors with general formula I and its derivate salts for use in the treatment of NRF2-related diseases caused by chronic inflammation and oxidative stress. More specifically the present invention relates to NRF2-betaTrCP interaction inhibitors with specific formula I and its derivate salts for treating diseases of the liver related with chronic inflammation and oxidative stress, such as fatty liver disease.
EUROPEAN PATENT APPLICATION
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)